2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140333
    Diethyl 10-bromodecylphosphonate 272785-01-0
    Diethyl 10-bromodecylphosphonate is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Diethyl 10-bromodecylphosphonate
  • HY-138491
    Iodoacetyl-PEG4-biotin
    Iodoacetyl-PEG4-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Iodoacetyl-PEG4-biotin
  • HY-140202
    Amino-PEG9-amido-C16-Boc
    Amino-PEG9-amido-C16-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG9-amido-C16-Boc
  • HY-W096099
    Nonylbenzene-PEG8-OH 41506-14-3
    Nonylbenzene-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Nonylbenzene-PEG8-OH
  • HY-130906
    DSPE-PEG46-N3
    DSPE-PEG46-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DSPE-PEG46-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    DSPE-PEG46-N3
  • HY-134692
    Azido-C1-PEG3-C3-NH2 1162336-72-2
    Azido-C1-PEG3-C3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-C1-PEG3-C3-NH2 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-C1-PEG3-C3-NH2
  • HY-141241
    Hydroxy-PEG3-C2-methyl ester 2086688-97-1
    Hydroxy-PEG3-C2-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-C2-methyl ester
  • HY-140816
    Azido-PEG2-hydrazide-Boc 2100306-56-5
    Azido-PEG2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-hydrazide-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-hydrazide-Boc
  • HY-132082
    Benzyl-PEG13-azide
    Benzyl-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG13-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzyl-PEG13-azide
  • HY-140686
    m-PEG-CH2COOH (MW 2000)
    m-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-CH2COOH (MW 2000)
  • HY-117041
    m-PEG4-CH2-aldehyde 1059189-65-9
    m-PEG4-CH2-aldehyde is a PEG-based based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG4-CH2-aldehyde
  • HY-140361
    m-PEG11-Tos
    m-PEG11-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG11-Tos
  • HY-134690
    Propanol-PEG4-CH2OH 156868-17-6
    Propanol-PEG4-CH2OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Propanol-PEG4-CH2OH
  • HY-130758
    Ald-PEG1-C2-Boc 2100306-48-5
    Ald-PEG1-C2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ald-PEG1-C2-Boc
  • HY-141279
    Methyltetrazine-PEG4-NH-Boc 2194563-84-1
    Methyltetrazine-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG4-NH-Boc
  • HY-138319
    Benzyl-PEG25-amine
    Benzyl-PEG25-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG25-amine
  • HY-124123
    Aminooxy-PEG4-alcohol 106492-60-8
    Aminooxy-PEG4-alcohol is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Aminooxy-PEG4-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG4-alcohol
  • HY-126977
    Propargyl-PEG9-OH 2055022-35-8
    Propargyl-PEG9-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG9-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG9-OH
  • HY-140952
    m-PEG24-DSPE
    m-PEG24-DSPE is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG24-DSPE
  • HY-141189
    TCO-PEG8-TCO 2353409-67-1
    TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    TCO-PEG8-TCO
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.